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Human Protein Atlas
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Human Protein Atlas
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Human Protein Atlas
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Image Search Results
Journal: American Journal of Cancer Research
Article Title: Low expression of cytosolic NOTCH1 predicts poor prognosis of breast cancer patients
doi:
Figure Lengend Snippet: Comparison of the expression of NOTCH1 mRNA and disease-free survival of breast cancer patients in the Kaplan-Meier Plotter. There are two probes of the NOTCH1 gene: the 218902_at probe is targeted on the 3’-UTR, and the 223508_at probe is targeted on Exon 34 of NOTCH1. A, B. All breast cancer patients. C, D. ER+ breast cancer patients. E, F. HER2+ breast cancer patients. G, H. TNBC patients. 3’-UTR: 3’-untranslated region; ER: estrogen receptor; HER2: human epidermal growth factor receptor Type II; HR: hazard ratio; mRNA: messenger ribonucleic acid; TNBC: triple negative breast cancer.
Article Snippet: The patients with high expression of NOTCH1 had a trend of poor survival after 10 years ( P = 0.22, ). fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window Figure 3 caption a7 Immunohistochemistry (IHC) of
Techniques: Comparison, Expressing
Journal: American Journal of Cancer Research
Article Title: Low expression of cytosolic NOTCH1 predicts poor prognosis of breast cancer patients
doi:
Figure Lengend Snippet: Comparison of NOTCH1 mutations in the cBioPortal platform. A. Somatic mutations of NOTCH1 in 13 studies. The x-axis indicates the sequencing number of amino acids, and the y-axis indicates the number of mutations in all studies. B. Details of NOTCH1 gene alterations in 13 studies. C. Comparison of disease-free survival between patients with altered or unaltered NOTCH1 genes. Altered group includes the patients with mutation, fusion, amplification, deep deletion, multiple alteration, and all forms of alteration of NOTCH1 gene. Unaltered group includes patients with wild type NOTCH1 gene in genome-wide sequencing. CNA: copy number alteration.
Article Snippet: The patients with high expression of NOTCH1 had a trend of poor survival after 10 years ( P = 0.22, ). fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window Figure 3 caption a7 Immunohistochemistry (IHC) of
Techniques: Comparison, Sequencing, Mutagenesis, Amplification, Genome Wide
Journal: American Journal of Cancer Research
Article Title: Low expression of cytosolic NOTCH1 predicts poor prognosis of breast cancer patients
doi:
Figure Lengend Snippet: Immunohistochemistry (IHC) of NOTCH1 in Human Protein Atlas. A. IHC staining of NOTCH1 in tissue microarrays. Left block: stain with CAB008112 antibody. Right block: stain with CAB022466 antibody. B. Results of IHC of NOTCH1. Arrow: more than 75% of cells had positive NOTCH1 staining. Arrowhead: Nuclear staining of NOTCH1. C. Comparison of overall survival between patients with low or high expression of NOTCH1.
Article Snippet: The patients with high expression of NOTCH1 had a trend of poor survival after 10 years ( P = 0.22, ). fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window Figure 3 caption a7 Immunohistochemistry (IHC) of
Techniques: Immunohistochemistry, Blocking Assay, Staining, Comparison, Expressing
Journal: American Journal of Cancer Research
Article Title: Low expression of cytosolic NOTCH1 predicts poor prognosis of breast cancer patients
doi:
Figure Lengend Snippet: Immunohistochemistry (IHC) staining of cNOTCH1 in breast cancer. A. Negative immunoreactivity. B. Weak immunoreactivity. C. Strong immunoreactivity. The main photos are 100× magnification with a 10-μm-scale bar in the left lower corner. The inserted photos in the right lower corner are 400× magnification with a 10-μm-scale bar. The tumors with negative and weak immunoreactivity are grouped as low cNOTCH1 expression, while those with strong immunoreactivity are grouped as high cNOTCH1 expression. D-I. Comparison of different pathological factors and expression of cNOTCH1 by IHC staining. D. Tumor size (P = 0.087). E. Extensive intraductal components (P = 0.009). F. Nipple invasion by cancer (P = 0.043). G. Tumor stage (P = 0.139). H. Nodal stage (P = 0.304). I. AJCC TNM stage (P = 0.063). AJCC TNM stage: American Joint Committee on Cancer tumor, node, metastasis staging system; cNOTCH1: cytosolic NOTCH1 protein.
Article Snippet: The patients with high expression of NOTCH1 had a trend of poor survival after 10 years ( P = 0.22, ). fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window Figure 3 caption a7 Immunohistochemistry (IHC) of
Techniques: Immunohistochemistry, Expressing, Comparison
Journal: American Journal of Cancer Research
Article Title: Low expression of cytosolic NOTCH1 predicts poor prognosis of breast cancer patients
doi:
Figure Lengend Snippet: Comparison of the expression of cNOTCH1 in immunohistochemistry (IHC) and disease-free survival of breast cancer patients. A. All breast cancer patients in the present study. B. ER+ breast cancer patients. C. HER2+ breast cancer patients. D. Triple negative breast cancer (TNBC) patients. E. The patients received standard chemotherapy.HER2: human epidermal growth factor receptor type II; cNOTCH1: cytosolic NOTCH1 protein; TNBC: triple negative breast cancer.
Article Snippet: The patients with high expression of NOTCH1 had a trend of poor survival after 10 years ( P = 0.22, ). fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window Figure 3 caption a7 Immunohistochemistry (IHC) of
Techniques: Comparison, Expressing, Immunohistochemistry
Journal: American Journal of Cancer Research
Article Title: Low expression of cytosolic NOTCH1 predicts poor prognosis of breast cancer patients
doi:
Figure Lengend Snippet: RNA sequencing data from The Cancer Genome Atlas Breast Invasive Carcinoma in Genomic Data Commons Data Portal (GDC TCGA-BRCA) via the Xena platform. Scatter plots of NOTCH1 versus (A) CCNA1 (protein: cyclin A1), (B) CCNA2 (protein: cyclin A2), (C) CCNB1 (protein: cyclin B1), (D) CCND1 (protein: cyclin D1), (E) CCND2 (protein: cyclin D2), (F) CCNE1 (protein: cyclin E1), (G) CDK2 (protein: CDK2), (H) CDK4 (protein: CDK4), (I) CDK6 (protein: CDK6), (J) CDKN1A (protein: p21), (K) CDKN1B (protein: p27), AND (L) CDKN2C (protein: p18). Adjusted P value was calculated by Benjamini-Hochberg procedure.
Article Snippet: The patients with high expression of NOTCH1 had a trend of poor survival after 10 years ( P = 0.22, ). fig ft0 fig mode=article f1 fig/graphic|fig/alternatives/graphic mode="anchored" m1 Open in a separate window Figure 3 caption a7 Immunohistochemistry (IHC) of
Techniques: RNA Sequencing
Journal: Journal of Neuroinflammation
Article Title: CRP gene variation affects early development of Alzheimer's disease-related plaques
doi: 10.1186/1742-2094-8-96
Figure Lengend Snippet: Co-localisation of CRP and Aβ immunohistochemical staining (a) Aβ staining (b) CRP staining (c) merge, 100 × magnification .
Article Snippet:
Techniques: Immunohistochemical staining, Staining
Journal: Journal of Neuroinflammation
Article Title: CRP gene variation affects early development of Alzheimer's disease-related plaques
doi: 10.1186/1742-2094-8-96
Figure Lengend Snippet: CRP SNPs and prevalence of CRP immunohistochemical staining (positive/negative) with SNPs rs3091244 and rs1130864 . Genotypes in order of population frequency, with * referring to 'no CRP staining' versus 'positive staining' with most common genotype as reference group.
Article Snippet:
Techniques: Immunohistochemical staining, Staining
Journal: Journal of Neuroinflammation
Article Title: CRP gene variation affects early development of Alzheimer's disease-related plaques
doi: 10.1186/1742-2094-8-96
Figure Lengend Snippet: Results validated by FDR < 0.05 cutoff limit
Article Snippet:
Techniques: Immunohistochemistry